Cenforce 130 mg, which contains sildenafil citrate as its active ingredient, can interact negatively with grapefruit or grapefruit juice. Grapefruit contains compounds known as furanocoumarins that inhibit the CYP3A4 enzyme in the liver. This enzyme is responsible for breaking down sildenafil in the body. When grapefruit is consumed, it slows down this process, leading to higher levels of sildenafil in the bloodstream. As a result, the effects of Cenforce 130 mg may become stronger and last longer than intended, increasing the risk of side effects such as headaches, flushing, dizziness, low blood pressure, or prolonged erections. To avoid complications, it is best to avoid grapefruit products while taking Cenforce 130 mg.