Viltra 20 Cyclic guanosine monophosphate (cGMP) plays a crucial role in achieving an erection because it increases the vasodilation of the penile muscles, increasing blood flow. However, is an enzyme known to break down cGMP and cause a weak erection. Vardenafil (the active substance in Vilitra) stops the activity of the PDE-5 enzyme by mimicking cGMP. It is structurally so similar to cGMP that the PDE-5 enzyme binds to Vardenafil instead of cGMP. A higher concentration of cGMP in the blood will increase blood circulation in the p*nis and help you get / maintain a firm erection during s*xual intercourse.