First, you have to learn the program with which you are going to work on the machine. You need it in order to load product layouts and place them on the working field of the machine. Then you set up the machine. This is usually taught when the machine is sold. At least Wattsan even gives online advice. Then you choose the material you want to work with and use the buttons on the machine to make it work.
More details here. What is a CNC CO2 laser and how does it work?