Tadalista 40, which contains 40 mg of tadalafil, is a medication used primarily to treat erectile dysfunction (ED) in men. The effects of Tadalista 40mg can last up to 36 hours, which is why it is sometimes referred to as the "weekend pill." Onset of action typically occurs within 30 to 60 minutes after ingestion, depending on factors like diet, metabolism, and individual response to the drug. While sexual stimulation is still required for the medication to work, its extended duration provides greater flexibility for sexual activity compared to shorter-acting ED medications. Tadalista 40 should not be taken more than once per day.