Common Dilaudid side effects may include:
- constipation, nausea, vomiting, or stomach pain
- dizziness, drowsiness
- feelings of extreme happiness or sadness
- sweating, mild itching
- dry mouth
- flushing (warmth, redness, or tingly feeling)

Serious side effects of Dilaudid include:
- a light-headed feeling
- sighing, noisy breathing, shallow breathing, or breathing that stops during sleep
- confusion, feelings of extreme happiness or sadness
- severe weakness or drowsiness
- infertility missed menstrual periods
- impotence, loss of interest in sex, or sexual problems
- low cortisol levels, including symptoms such as nausea, loss of appetite, worsening tiredness or weakness, vomiting, or dizziness