Fildena 50 is an inhibitor of phosphodiesterase type 5. This means it prevents the hydrolysis of cGMP. This enables cGMP to stay in the active site of PDE5, which prolongs its vasodilating effects on blood vessels, smooth muscle, and the penis.
cGMP is a major component of the body's natural erection, and nitric oxide (NO)-induced cGMP levels are responsible for the relaxation and vasodilation of the intimal cushion of the helicine arteries, which leads to increased blood flow into the spongy tissue of the penis . This vasodilation directly results from NO-releasing the enzyme guanylate cyclase, which converts guanosine triphosphate to cGMP. Normally, the cGMP level is not high enough to cause erectile dysfunction.
The induction of cGMP is controlled by the activity of a second enzyme, nitric oxide synthase (NOS), which releases NO from endothelial cells and activates guanylate cyclase. The resulting increase in NO levels leads to a cascade of reactions that ultimately lead to cGMP production.
This cGMP then travels through the bloodstream to the corpus cavernosum, triggering an erection. Notably, this effect is a direct response to sexual stimulation and occurs only in the presence of NO.
In a study of rats, NOS activation and cGMP accumulation in the corpus cavernosum was blocked by sildenafil. Moreover, nitric oxide-induced cGMP accumulation in the guinea pig's corpus cavernosum was also prevented by sildenafil.
In healthy male subjects, sildenafil administration produced a small rise in plasma cGMP and cAMP (paired t-test of the area under the curve). However, there was no significant change in plasma CGRP after sildenafil compared with the placebo.
It is a medication that is a phosphodiesterase inhibitor. This means that it blocks the activity of an enzyme called phosphodiesterase 5. The blocking of this enzyme prevents a chemical reaction in your body that produces substances called cAMP and cGMP.
These substances regulate cell function and help control blood pressure, heart rate, and the flow of nutrients to your cells. They also cause the body to relax, so they are often used to treat high blood pressure and erectile dysfunction (ED).
Another important part of sildenafil is that it is very good at relaxing your blood vessels. This can be very helpful in ED and pulmonary arterial hypertension (PAH), which causes the narrowing of the arteries that carry blood from your heart to the lungs.
The relaxation of your blood vessels can be triggered by the release of neurogenic nitric oxide and norepinephrine from your brain. These two chemicals can bind to receptors in your arteries and veins and cause your vascular walls to relax.
This can lead to increased blood flow in the arteries and veins, which increases your ability to get an erection. It can also increase the amount of oxygen in your blood.
It is important to note that when you take this drug, it should be taken as directed by your doctor. It should not be taken with nitrates or other medicines that reduce blood pressure because these combinations can cause a dangerous drop in your blood pressure.
Taking sildenafil with other medicines can also make it less effective, so it is important to check with your doctor if you are on any other medications. This is especially true if you take blood pressure-lowering drugs or alcohol because these substances can interact with sildenafil and make it less effective.
The main component of Fildena 50 Pill is sildenafil citrate, a phosphodiesterase inhibitor. PDE5 is an enzyme that breaks down cAMP and cGMP, the two chemicals that regulate blood pressure, heart rate, and the flow and tone of your muscles.
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