Fildena 100 Mg - PDE5 inhibitors are a group of medications that increase the flow of blood to the penile area. They are used in the treatment of erectile dysfunction (ED), pulmonary hypertension, and peripheral neuropathy.
PDE5 inhibitors should be administered in steps, as they can lead to hypotension. They should also be avoided in patients with cardiovascular disease, diabetes, or comorbid comorbidities. PDE5 inhibitors are safe to use when co-administered with ranolazine, an anti-hypertensive medication. However, the FDA has issued warnings about PDE5I-related hearing loss.
PDE5 inhibitors work by enhancing the action of nitric oxide (NO) on the cavernous nerve. This action stimulates the formation of cGMP. This cGMP is then transported into adjacent smooth muscle cells, leading to vasodilation. In addition, PDE5 inhibitors inhibit ejaculatory latency, thus improving erectile function.
Whether you are new to the medication or have been using it for some time, it is important to be aware of the risks and side effects associated with PDE5 inhibitors. This article discusses the benefits and disadvantages of these medications and how they compare to other treatments.
Ideally, the ideal patient for PDE5 inhibitor therapy is a patient with no severe complications, but who can take the medication on a regular basis. Patients should also be warned against co-administration of PDE5 inhibitors with nitrates.
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