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The American Society for Clinical Pathology (ASCP) is a professional organization dedicated to advancing the field of laboratory medicine and promoting excellence in patient care. One of the ways the ASCP achieves this goal is through certification exams, including the ASCP-MLT (Medical Laboratory Technician) Certification Exam. ASCP-MLT exam is designed to test the knowledge and skills of individuals seeking certification as a medical laboratory technician.
To become eligible to take the ASCP-MLT Certification Exam, candidates must possess either an associate’s degree in medical laboratory technology from an accredited institution or have completed a military medical laboratory training program. Additionally, candidates must have completed the required clinical laboratory experience or training.
ASCP-MLT certification exam is an important step for medical laboratory technicians who wish to demonstrate their knowledge and skills in the field of laboratory medicine. MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) certification is recognized by employers and state licensure agencies and is a requirement for many laboratory positions. Candidates who pass the exam and become certified by the ASCP have the opportunity to advance their careers and increase their earning potential.
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NEW QUESTION # 277
Rule-out is a process by which antibodies are identified as being unlikely in a given sample because of the absence of an expected antigen-antibody reaction. In other words, the absence of a reaction is noted with a cell that is positive for the corresponding antigen.
Although rule-out procedures may vary somewhat from institution to institution, the following general principles apply:
Non-reactive cells are selected for rule-out. To be classified as non-reactive, a cell must NOT have reacted at any phase of testing in a given panel or screen.
Using the logic that if the rule-out cell is positive for a given antigen, it should have reacted with the corresponding antibody, you can rule-out antibodies that correspond to antigen positive cells.
To increase the probability that rule-out will not mistakenly eliminate a weakly-reacting antibody that exhibits dosage*, use only cells that are homozygous for the corresponding antigen for those systems that generally show dosage. Generally these include: C, c, E, e, Fya, Fyb, Jka, Jkb, M, N, S, and s.
In this case, it is only possible to rule out on screening cell 2 since it demonstrates a negative reaction with the patient serum. Anti-C cannot be ruled out since the C antigen is heterozygous on screening cell 2 with c.
Anti-Fya cannot be ruled out since this antigen is not present on screening cell 2. Anti-M and anti-Jka can be ruled out since the antigens are homozyous while demonstrating a negative reaction on screening cell 2.
Rule-out, while very useful, can lead to error. Ruling out an antibody should be combined with other supporting data to increase confidence in the solution; the more data collected, the higher the probability that the final solution is correct.
*Dosage means that there are two "doses" of the same antigen present on the red cells . Antibodies that exhibit dosage react more strongly with homozygous cells (e.g., Jka Jka) than with heterozygous cells (e.g., Jka Jkb) .
Based on the phenotype of the RBC screening cells, and patient results shown on the right, which of the following antibodies CANNOT be ruled out?
Answer: A,B
NEW QUESTION # 278
Hematology
What is Coombs sera comprised of:
Answer: B
NEW QUESTION # 279
A positive spot test shows agglutination of horse erythrocytes when added to patient serum previously absorbed with guinea pig kidney, but not when added to patient serum previously absorbed with beef erythrocyte stroma. The test is generally simple, sensitive, and specific, but false negative are common in young children with mononucleosis.
The most common rapid slide test (MONOSPOT©) for infectious mononucleosis employs:
Answer: D
NEW QUESTION # 280
Which one of the following conditions is NOT associated with hereditary spherocytosis?
Answer: A
NEW QUESTION # 281
May-Hegglin anomaly is a rare autosomal dominant condition in which patients are at risk for bleeding and infections. It is characterized by the presence of large Dohle body like inclusions within neutrophils, eosinophils, basophils, and monocytes.
The WBC anomaly indicated by the arrow in this illustration is:
Answer: D
NEW QUESTION # 282
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