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CAR T-cell therapy is succesful in treating some blood cancers & challenegs in solid tumors, antigen spacing including poor infiltration. Future Stratrigies including focus on improve CAR T Cell persistence, enhancing the tumor infiltration. General Challlenges are Cytokine Release Syndrome and neurotoxicity.Using Nanoparticles or oncloytic viruses to deliver Car T cell directly to the tumor.eveloping CARs that target multiple antigens combining CAR-T therapy with chemotherapy or other targeted therapy.
