Malegra-DXT will start working right away. Erectile dysfunction is a name of condition when cGMP enzyme is replaced by another enzyme PDE5 (phosphodiesterase type-5). PDE5 enzyme breaks down cGMP and takes its place. Blood flow is restricted by PDE5 enzyme leading to causing erection problem in men. Blood is essential for erection achievement. Malegra-DXT inhibits PDE5 enzyme, enhancing blood flow to the penile area. Blood filled penile region makes it easier for men to achieve erection. The drug is quickly absorbed after oral administration. The time after which the plasma concentration of the drug is highest is about 60 minutes; if the drug is taken during a meal, this time can be extended by another 60 minutes