Vriligy 60 mg is a medication used to treat premature ejaculation (PE) in men. It contains Dapoxetine as its active ingredient. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of serotonin in the brain, which helps to delay ejaculation and improve control over ejaculation.
When considering how Vriligy 60 mg interacts with other medications, it's essential to be aware of potential drug interactions. Dapoxetine, the active ingredient in Vriligy, can interact with certain medications, including:
Monoamine oxidase inhibitors (MAOIs): Taking Dapoxetine with MAOIs or within 14 days of stopping MAOIs can lead to serious side effects such as serotonin syndrome, a potentially life-threatening condition characterized by high levels of serotonin in the body.
Selective serotonin reuptake inhibitors (SSRIs): Combining Dapoxetine with other SSRIs or antidepressants may increase the risk of serotonin syndrome or other side effects.
Thioridazine: Thioridazine and Dapoxetine should not be taken together due to the potential for serious cardiac effects.
Serotonergic medications: Medications that increase serotonin levels, such as certain antidepressants, migraine medications (e.g., triptans), and some opioids, may increase the risk of serotonin syndrome when taken with Dapoxetine.
CYP3A4 inhibitors and inducers: Dapoxetine is metabolized primarily by the CYP3A4 enzyme system. Therefore, medications that inhibit or induce CYP3A4 activity may affect the metabolism and efficacy of Dapoxetine. Examples of CYP3A4 inhibitors include ketoconazole, ritonavir, and clarithromycin, while inducers include rifampicin, carbamazepine, and phenytoin.
Alcohol: Combining alcohol with Dapoxetine may increase the risk of dizziness, drowsiness, and impaired cognitive function.
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